Water → HCID 118216479, compound

Participants

Reaction Steps

Methanesulfonyl chloride (1.36 g, 11.1 mmol) and triethylamine (2.51 mL, 18.4 mmol) were added to a solution of 7-(hydroxymethyl)-6-oxa-4-azaspiro[2.4]heptan-5-one (1.32 g, 9.2 mmol) in DCM (47 mL) at 0° C. and this mixture was stirred at room temperature for 3 hours. The reaction mixture was then poured into water and extracted with ethyl acetate (10 mL×3). The combined organic layer was dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by chromatography on silica gel (ethyl acetate) to afford (5-oxo-6-oxa-4-azaspiro[2.4]hept-7-yl)methyl methanesulfonate. MS ESI calc'd. for C7H12NO5S [M+H]+ 222. found 222.

Provenance & Evidence