HCID 118208576, compound → HCID 118208624, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(2,4-dimethoxybenzyl)-4-{1-[4-(4-methyl-6-{[4-(trifluoromethyl)-pyridin-2-yl]amino}pyridin-2-yl)-1H-pyrazol-1-yl]ethyl}pyrrolidin-2-one (100 mg, 0.17 mmol) in TFA (5 mL) was stirred at 60° C. for 3 hours. The solvent was removed under reduced pressure and the crude product was purified by reverse phase HPLC (ACN/water with 0.1% formic acid modifier) to afford 4-{1-[4-(4-methyl-6-{[4-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1H-pyrazol-1-yl]ethyl}pyrrolidin-2one.

Provenance & Evidence