Phosphate → HCID 72707041, compound

Participants

Reaction Conditions

Reaction Steps

TFA (1.17 ml, 15.2 mmol) was added to a stirred solution of tert-butyl [4-(4-methyl-6-{[4-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1H-pyrazol-1-yl]acetate (330 mg, 0.76 mmol) in DCM (3.8 ml) at room temperature. The reaction mixture was stirred at 40° C. overnight. Upon cooling, the reaction mixture was poured into phosphate buffer pH 4 and extracted with EtOAc (2×30 mL). The combined organic layers were washed with brine, dried with magnesium sulfate and concentrated under reduced pressure. The residue was triturated in Et2O to afford [4-(4-methyl-6-{[4-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1H-pyrazol-1-yl]acetic acid as a pale yellow solid. [M+H]+ 378. found, 378

Provenance & Evidence