(1S)-2-Nitro-1-[3-({3-[(phenylmethyl)oxy]propyl}oxy)phenyl]ethanol → HCID 68226281, compound

HRID 595342Notes

Reaction equation

HRID 595342 reaction equation
[N+:1]([CH2:4][C@H:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH2:14][CH2:15][CH2:16][O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:8]=1)[OH:6])([O-])=O>C(O)C.[Pd]>[NH2:1][CH2:4][C@H:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH2:14][CH2:15][CH2:16][O:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:8]=1)[OH:6]

Participants

4

Reactant 1

HCID 56926628(1S)-2-Nitro-1-[3-({3-[(phenylmethyl)oxy]propyl}oxy)phenyl]ethanol

Product 1

HCID 68226281HCID 68226281, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The (1S)-2-nitro-1-[3-({3-[(phenylmethyl)oxy]propyl}oxy)phenyl]ethanol in ethanol solution (8 g in 160 mL) was hydrogenated using a Pd (4%)/Pt(1%)/C catalyst (1.6 g). Upon consumption of the starting material and the hydroxylamine intermediate, the reaction product in ethanol was filtered.

Workup

  1. customUpon consumption of the starting material
  2. filtrationthe hydroxylamine intermediate, the reaction product in ethanol was filtered

Sources & evidence

ORD record
ord-415c6d80fc1b4407b387a5d440db7f3d
Source dataset
uspto-grants-2016_01
Patent number
US09243003B2

Reaction notes

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