反应详情

This reaction is carried out in the same manner as the reaction in example 3. The difference is that, the reactants are 4-Benzoylphenyl chloride (216.3 mg, 1.0 mmol), palladium cinnamyl chloride (7.8 mg, 0.015 mmol), 2-Methoxy-6-(N-methyl-N-phenyl-amino) henyldicyclohexyl)phosphine (24.5 mg, 0.060 mmol), Cs2OC3 (651.5 mg, 2.0 mmol) in 4.0 mL acetone at 90° C. for 12 h. 1-(4′-Benzoylphenyl)-2-propanone (195.2 mg) was obtained with a yield of 82% as liquid. 1H NMR (300 MHz, CDCl3) δ 7.83-7.75 (m, 4H, ArH), 7.62-7.54 (m, 1H, ArH), 7.52-7.43 (m, 2H, ArH), 7.35-7.28 (m, 2H, ArH), 3.81 (s, 2H, CH2), 2.22 (s, 3H, CH3); 13C NMR (75 MHz, CDCl3) δ 205.1, 196.1, 138.8, 137.4, 136.1, 132.3, 130.3, 129.8, 129.3, 128.1, 50.5, 29.5; IR (neat) v (cm−1) 3059, 3003, 2917, 1715, 1660, 1651, 1606, 1579, 1447, 1416, 1358, 1317, 1278, 1227, 1178, 1159, 1113, 1075, 1020, 1001; MS (70 eV, EI) m/z (%): 239 (M++1, 0.98), 238 (M+, 5.45), 196 (100).

1. customThis reaction is carried out in the same manner as the reaction in example 3
2. customat 90° C.
3. customfor 12 h