HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic Acid → N'-benzoyl-6-chloro-4-(isopropylamino)nicotinohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 6-Chloro-4-(isopropylamino)nicotinohydrazide | HCID 89689668 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N'-benzoyl-6-chloro-4-(isopropylamino)nicotinohydrazide | HCID 89689702 | — |
Reaction Steps
6-chloro-4-(isopropylamino)nicotinohydrazide (10) (500 mg, 2.1 mmol) and benzoic acid (2.1 mmol, 1 equiv.) were dissolved in DMF (10 mL). EDC.HCl (1.5 equiv.), DIPEA (3 equiv.) and HOBT (1.5 equiv.) were added to the reaction mixture and stirred at room temperature for 5 h. The reaction mass was concentrated under reduced pressure to remove excess of solvent present. Diluted the residue with EtOAc and washed water followed by brine solution. The organic layer was collected, dried over Na2SO4, filtered and concentrated to get N′-benzoyl-6-chloro-4-(isopropylamino)nicotinohydrazide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242975B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-4cc06ae56bfc4f3fb1b9aef0139a49f5 |
| Source note | uspto-grants-2016_01 |