Cyclobut A → 9-(2'-(Hydroxymethyl)-3'-methylcyclobutyl)adenine

HRID 5955Notes

Reaction equation

OCC1C(CO)CC1N1C=NC2C(=O)NC(N)=NC1=2.[OH:20][CH2:21][CH:22]1[CH:25]([CH2:26]O)[CH2:24][CH:23]1[N:28]1[CH:36]=[N:35][C:34]2[C:29]1=[N:30][CH:31]=[N:32][C:33]=2[NH2:37]>>[OH:20][CH2:21][CH:22]1[CH:25]([CH3:26])[CH2:24][CH:23]1[N:28]1[CH:36]=[N:35][C:34]2[C:29]1=[N:30][CH:31]=[N:32][C:33]=2[NH2:37]

Participants

Reactant 2

HCID 122100Cyclobut A

HCID 135839365HCID 135839365, compound

Product 1

HCID 197943299-(2'-(Hydroxymethyl)-3'-methylcyclobutyl)adenine

Procedure

Following the procedures described in Example 40, replacing 9-(2',3'-bis(hydroxymethyl)-cyclobutyl)guanine, the product of Example 1, with 9-(2',3'-bis(hydroxymethyl)cyclobutyl)adenine, Example 4, the title compound is prepared.

Sources & evidence

ORD record: ord-24435b4afdfa4eebb5264d51b0d621a6
Source dataset: uspto-grants-1993_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05246931

Reaction notes

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