Sodium Carbonate → 5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(2-methoxypyridin-4-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Participants

Reaction Conditions

Reaction Steps

To a degassed solution of 2-(2-methoxypyridin-4-yl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide (60 mg, 0.12 mmol), 2-chloro-11-fluoro-6H-pyrido[2′,3′:5,6][1,3]oxazino[3,4-a]indole (35 mg, 0.13 mmol) and Na2CO3 (25 mg, 0.23 mmol) in dioxane (1.5 mL) and H2O (0.1 mL) was added Pd2(dba)3 (3 mg) and X-Phos (3 mg) under N2. Then the mixture was stirred at 100° C. for 2 hours. The reaction mixture was cooled to RT and filtered. The filtrate was washed with H2O and dried over Na2SO4. After concentrated, the residue was purified by prep-HPLC to give the product of 5-(11-fluoro-6H-pyrido[2′,3′:5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(2-methoxypyridin-4-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (35 mg, yield: 48%). 1H-NMR (CDCl3, 400 MHz) δ 8.29 (s, 1H), 8.28 (s, 1H), 7.98 (s, 1H), 7.69 (s, 2H), 7.40˜7.49 (m, 1H), 7.30 (s, 1H), 7.19˜7.24 (m, 2H), 7.10˜7.18 (m, 1H), 6.82˜6.87 (m, 1H), 6.11 (s, 1H), 5.99 (s, 2H), 3.99 (s, 3H), 3.36 (s, 3H), 3.04 (d, J=4.8 Hz, 3H), 2.75 (s, 3H). MS (M+H)+: 628.

Provenance & Evidence