5-Bromo-2-fluoropyridine → 6-amino-5-bromo-2-(6-fluoropyridin-3-yl)-N-methylbenzofuran-3-carboxamide

Participants

Reaction Conditions

Reaction Steps

To a solution of (6-amino-5-bromo-3-(methylcarbamoyl)benzofuran-2-yl)boronic acid (500 mg, 1.61 mmol) in dioxane/H2O (5 mL/0.5 mL) was added 5-bromo-2-fluoropyridine (420 mg, 2.42 mmol), Pd(dppf)Cl2(10 mg) and K3PO4.3H2O (855 mg, 3.21 mmol). The mixture was stirred at 50° C. for 10 h. The mixture was evaporated and washed with MeOH to obtain the yellow solid as the product of 6-amino-5-bromo-2-(6-fluoropyridin-3-yl)-N-methylbenzofuran-3-carboxamide (300 mg, yield: 51%). 1H-NMR (DMSO-d6, 400 MHz) δ 8.76 (s, 1H), 8.44˜8.51 (m, 2H), 7.75 (s, 1H), 7.39˜7.42 (m, 1H), 7.09 (s, 1H), 5.71 (s, 2H), 2.88 (d, J=8.4 Hz, 3H). (M+H)+: 364/366.

Provenance & Evidence