4-Bromophenol → HCID 90332535, compound

Participants

Reaction Conditions

Reaction Steps

(t-BuO)2 (94 g, 640 mol) was added to a solution of ethyl 3-cyclopropyl-3-oxopropanoate (50 g, 320 mmol), 4-bromophenol (166 g, 9.6 mol) and FeCl.6H2O (5.8 g, 32 mmol) in Di-chlorine Ethane (316 g, 3.2 mol) under N2 gas at 25° C. The mixture was stirred at 80° C. for 6 hours. The solvent was removed and the residue was purified by column chromatography (eluted with PE:EA from 20:1 to 10:1) to furnish the pure product of ethyl 5-bromo-2-cyclopropylbenzofuran-3-carboxylate (20.0 g, yield: 21%). 1H-NMR (400 MHz, CDCl3) δ 8.02 (s, 1H), 7.30 (d, J=7.2 Hz, 1H), 7.18 (d, J=7.2 Hz, 1H), 4.42 (q, J=7.2 Hz, 2H), 3.01˜3.05 (m, 1H), 1.44 (t, J=7.2 Hz, 3H), 1.24˜1.26 (m, 2H), 1.16˜1.19 (m, 2H). MS (M+H)+: 309/311.

Provenance & Evidence