HCID 90333619, compound → HCID 178485243, compound

Participants

Reaction Steps

A degassed solution of 5-(benzyloxy)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxamide (3.0 g, 6.2 mmol) in THF (50 mL) was charged with 10% palladium on carbon (0.3 g). The reaction mixture was hydrogenated at room temperature under H2 balloon for 4 hours. The reaction mixture was filtered, and washed with DMF twice. The filtrate concentrated in vacuo and dried to afford pure 2-(4-fluorophenyl)-5-hydroxy-N-methyl-6-(N-methylmethylsulfonamido) pyrazolo[1,5-a]pyridine-3-carboxamide (2.3 g, yield: 94%). MS (M+H)+: 393.

Provenance & Evidence