反应详情

To a solution of tert-butyl 2-(6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-3-(2-hydroxyethyl)pyridin-2-yl)-3-methyl-1H-indole-1-carboxylate (50 mg, 0.069 mmol) in CH2Cl2 (1.5 mL) was added TFA (1.5 mL). The resultant mixture was stirred at ambient temperature for 1.5 h then was concentrated in vacuo, diluted with EtOAc and washed successively with saturated NaHCO3 (aq) solution (1×) and brine (1×). The organic layer was dried over MgSO4, filtered, and concentrated in vacuo to give the title compound, which was used without further purification. MS (M+H): 627.

1. concentrationthen was concentrated in vacuo
2. additiondiluted with EtOAc
3. washwashed successively with saturated NaHCO3 (aq) solution (1×) and brine (1×)
4. dry with materialThe organic layer was dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo