Triphenylphosphine → HCID 90332545, compound

Participants

Reaction Steps

5-(6-(4-fluoro-1H-indol-2-yl)-5-(hydroxymethyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (280 mg, 0.45 mmol) was dissolved in THF (8 mL). To the resulting mixture was added diisopropyl azodicarboxylate (184 mg, 0.91 mmol) and PPh3 (238 mg, 0.91 mmol). The resulting mixture was stirred at RT overnight. Preparative TLC gave 5-(10-fluoro-5H-pyrido[2′,3′:3,4]pyrrolo[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (230 mg, yield: 85%) MS (M+H)+: 599.

Provenance & Evidence