HCID 90333624, compound → HCID 90333458, compound

Participants

Reaction Steps

To a solution of 5-(5-(2-(benzyloxy)-1-fluoroethyl)-6-(4-fluoro-1H-indol-2-yl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (530 mg, 0.717 mmol) in THF (10 mL) was added palladium hydroxide (101 mg, 0.717 mmol). The mixture was hydrogenated under a balloon for 2 h. Filtration through a pad of celite removed the solid. After washing with ethyl acetate, the combined filtrate was concentrated in vacuo to give 5-(6-(4-fluoro-1H-indol-2-yl)-5-(1-fluoro-2-hydroxyethyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (465 mg, yield: 100%). MS (M+H)+: 649.

Provenance & Evidence