Triphenylphosphine → HCID 90341041, compound

Participants

Reaction Steps

To a solution of 5-(6-(4-fluoro-1H-indol-2-yl)-5-(1-fluoro-2-hydroxyethyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (465 mg, 0.717 mmol) and triphenylphosphine (282 mg, 1.075 mmol) in DCM (15 mL) was added diisopropyl azodicarboxylate (217 mg, 1.075 mmol). The resulting mixture was stirred at RT overnight and concentrated in vacuo. The resulting residue was purified using column chromatography (eluted with 20-50% ethyl acetate/hexane) to provide 5-(5,11-difluoro-5,6-dihydroindolo[1,2-h][1,7]naphthyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (250 mg, yield: 55%). MS (M+H)+: 631.

Provenance & Evidence