HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 595774Generated: October 29, 2026
Ammonium Chloride → (6-Bromo-2-chloropyridin-3-yl)methanol
https://huagongshe.com/reaction/595774
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 6-Bromo-2-chloropyridine-3-carbaldehyde | HCID 45588196 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (6-Bromo-2-chloropyridin-3-yl)methanol | HCID 70701001 | 101% |
Reaction Steps
To a solution of 6-bromo-2-chloronicotinaldehyde (5.40 g, 24.50 mmol) in THF (30 ml) and MeOH (10.0 ml) at 0° C. was added NaBH4 (0.927 g, 24.50 mmol). The mixture was stirred at 0° C. for 2 h. Saturated NH4Cl (50 ml) was added and the mixture extracted with ethyl acetate, dried over (Na2SO4), filtered and concentrated in vacuo to give (6-bromo-2-chloropyridin-3-yl)methanol (5.50 mg, yield: 101%). MS (M+H)+: 224.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09243002B2 |
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| Source dataset | uspto-grants-2016_01 |
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| ORD ID | ord-8be3375d4c234d3aa54baffbd5a15feb |
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| Source note | uspto-grants-2016_01 |
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