HCID 118046042, compound → HCID 118045832, compound

Participants

Reaction Steps

5-(4,5-dihydrothiophen-3-yl)pyridin-2-amine(0.78 g, 4.38 mmol) was dissolved in ethanol(30 mL), to it was added Pd—C (Deggussa, 10%, 0.233 g) and the mixture was stirred under H2 balloon overnight. The reaction was not complete by LCMS. The Pd—C catalyst was removed by filtering through a Celite pad, and to the filtrate was added new Pd—C catalyst (0.24 g), and the mixture was stirred under H2 balloon under same condition for another 6 h. The reaction mixture was filtered off through Celite pad, and the filtrate was concentrated under reduced pressure yielding 5-(tetrahydrothiophen-3-yl)pyridin-2-amine (0.661 g, 84%) as colorless oil. LCMS (m/z): 181.2 (MH+), 0.39 min.

Provenance & Evidence