N-bromobutanimide → HCID 118045604, compound

Participants

Reaction Conditions

Reaction Steps

3-(6-aminopyridin-3-yl)tetrahydrothiophene 1,1-dioxide (96 mg, 0.452 mmol) was dissolved in acetonitrile (5 mL) and the solution was cooled to 0° C., to it was added NBS (80 mg, 0.452 mmol) and the mixture was stirred at 0° C. for 40 min. The reaction mixture was concentrated under reduced pressure and the residue was partitioned between EtOAc/sat. NaHCO3 (30 mL/20 mL), the EtOAc layer was washed with sat. Na2CO3 (20 mL), brine (20 mL), dried (Na2SO4), filtered off and concentrated in vacuo yielding 3-(6-amino-5-bromopyridin-3-yl)tetrahydrothiophene 1,1-dioxide as light brown oil (50 mg, 38% yield). LCMS (m/z): 293.0/291.0 (MH+), 0.29 min.

Provenance & Evidence