N-bromobutanimide → HCID 123354204, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-((1R,3S)-3-((tert-butyldimethylsilyl)oxy)cyclohexyl)pyrazin-2-amine (110 mg, 0.358 mmol) in acetonitrile (5.50 mL) was added NBS (66.9 mg, 0.376 mmol) at 0° C. The reaction mixture was stirred at 0° C. for 15 min. After quenched with sat sodium thiosulfate and sat NaHCO3, extracted with EtOAc three times. The organic layers were combined and washed with brine, dried over Na2SO4, filtered and concentrated to afford 138 mg of desired cis racemate compound, which was used as it was. LCMS (m/z): 388 (MH+), 0.72 min.

Provenance & Evidence