Hydrochloric Acid → HCID 118045394, compound

Participants

Reaction Steps

To 5-(1,4-dioxaspiro[4.5]decan-8-yl)pyrazin-2-amine (8.68 g, 45.4 mmol) was added acetonitrile (368 mL), water (245 mL) and 3M HCl (76 mL). The reaction was stirred at room temperature for 30 min. The reaction was basified with excess 1M NaOH, and then diluted with of ethyl acetate. The organic layer was separated. The aqueous layer was extracted well with EtOAc/2-methyl THF (1:1) three times. Organic layers were combined and dried over Na2SO4, filtered and concentrated to give 6.91 g of product as free base. LCMS (m/z): 192.12 (MH+), 0.30 min.

Provenance & Evidence