HCID 118045520, compound → HCID 118046020, compound

HRID 595893Notes

Reaction equation

HRID 595893 reaction equation
[CH2:1]([O:3]/[CH:4]=[CH:5]/[C:6]1[N:7]=[CH:8][C:9]([NH2:12])=[N:10][CH:11]=1)[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][CH2:4][CH2:5][C:6]1[N:7]=[CH:8][C:9]([NH2:12])=[N:10][CH:11]=1)[CH3:2]

Participants

4

Reactant 1

HCID 118045520HCID 118045520, compound

Product 1

HCID 118046020HCID 118046020, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of (E)-5-(2-ethoxyvinyl)pyrazin-2-amine (75 mg, 0.454 mmol) in ethanol (4.54 mL) was added Pd/C (48.3 mg, 0.454 mmol). The reaction mixture was purged by nitrogen for 10 min, and then stirred at room temperature for 2 h under hydrogen balloon. The reaction mixture was then filtered through Celite and washed with methanol and EtOAc, then concentrated. The crude product was used in next step reaction without purification. LCMS (m/z): 168.1 (MH+), 0.33 min.

Workup

  1. customThe reaction mixture was purged by nitrogen for 10 min
  2. filtrationThe reaction mixture was then filtered through Celite
  3. washwashed with methanol and EtOAc
  4. concentrationconcentrated
  5. customThe crude product was used in next step reaction without purification
  6. custom168.1 (MH+), 0.33 min.

Sources & evidence

ORD record
ord-bfd9c5d2a11e42719fbaef79fb52b5ad
Source dataset
uspto-grants-2016_01
Patent number
US09242996B2

Reaction notes

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