反应详情

温度

56 °C

Under Argon, to ethyl 4-(5-(tert-butoxycarbonylamino)pyrazin-2-yl)-4-cyanobutanoate in ethanol solution (94 mg, 0.281 mmol/8 mL) was added Raney Nickel catalyst ethanol suspension (Nickel in ˜2 mL ethanol, the amount of Raney Nickel was not accurately measured), and the reaction mixture was stirred under H2 balloon after 3 times air atomasphere exchange heated with external oil bath at 56° C. for overnight with H2 balloon. The reaction mixture was cooled down to room temperature, and filtered through a pad of Celite, the filtrate was concentrated to afford tert-butyl 5-(6-oxopiperidin-3-yl)pyrazin-2-ylcarbamate in a yellow solid.

1. temperatureThe reaction mixture was cooled down to room temperature
2. filtrationfiltered through a pad of Celite
3. concentrationthe filtrate was concentrated