反应详情

温度

0 °C

To a solution of (S)-4-(3-aminopyrazin-2-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-2-fluorobenzamide (389 mg, 1.006 mmol) in acetonitrile (21 mL) was added NBS (171 mg, 0.961 mmol) at 0° C. The reaction mixture was stirred at 0° C. for 20 min. After quenched with sat NaHCO3, and stir for 30 min. The reaction mixture was extracted with EtOAc 3 times, the organic was washed by sat NaHCO3, water and brine, dried, filtered off, and concentrated. The crude material was taken to the next step without further purification. LCMS (m/z): 367 (MH+), 0.88 min.

1. customAfter quenched with sat NaHCO3
2. stirringstir for 30 min
3. extractionThe reaction mixture was extracted with EtOAc 3 times
4. washthe organic was washed
5. customdried
6. filtrationfiltered off
7. concentrationconcentrated
8. customThe crude material was taken to the next step without further purification
9. custom367 (MH+), 0.88 min.