Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Methyl 4-bromo-2,6-difluorobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 반응물 | 4-Bromo-2,6-difluorobenzoic acid | HCID 2773298 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl 4-bromo-2,6-difluorobenzoate | HCID 26343953 | 47% |
반응 단계
To a solution of 4-bromo-2,6-difluorobenzoic acid (800 mg, 3.38 mmol) in MeOH (11 mL) at room temperature, trimethylsilyldiazomethane (5.63 mL, 3.38 mmol) was slowly added until yellow solution was turned on. The small amount of AcOH was added until yellow color disappered. All volatile materials were removed in vacuo yielding methyl 4-bromo-2,6-difluorobenzoate (47%). LCMS (m/z): 251.1 (MH+), 0.86 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09242996B2 |
| 출처 데이터셋 | uspto-grants-2016_01 |
| ORD ID | ord-5bb0810bb675496892a635137c9c90a6 |
| 출처 메모 | uspto-grants-2016_01 |