Lithium Hydroxide → 4-(3-Amino-6-(oxetan-3-yl)pyrazin-2-yl)-2-fluorobenzoic acid

Participants

Reaction Steps

To methyl 4-(3-amino-6-(oxetan-3-yl)pyrazin-2-yl)-2-fluorobenzoate (13 mg, 0.043 mmol) in MeOH (1 mL) and THF (2 mL) was added LiOH (0.128 mL, 0.128 mmol). The reaction mixture was stirred 2 h at room temperature. The reaction mixtures was adjusted to acidic (pH˜3) and solvent was evaporated on rotovap. The crude was azeotrope with toluene and proceed for next step. LCMS (m/z): 290.1 (MH+), 0.46 min.

Provenance & Evidence