HRID596137

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21946426

未命名化合物

结构：CCCCCCCCC1(CCCCCCCC)c2cc(Br)ccc2-c2ccc(-c3ccc(Br)cc3C(=O)OC)cc21

HCID86723550

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCC1(CCCCCCCC)c2cc(Br)ccc2-c2ccc(-c3ccc(Br)cc3C(=O)O)cc21

HCID58607538

未命名化合物

收率 102.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

35 g (51.2 mmol) 16 is suspended in 300 ml ethanol and treated with 50 ml 50% KOH/ethanol solution and heated to reflux for 3 h. After cooling to room temperature with reaction mixture is diluted with 200 ml ethanol, with precipitation is collected by filtration, the residue is washed with ethanol and dried in vacuum. 35 g (yield: 98%) of a white solid can be obtained.

WORKUP

后处理

temperatureheated
temperatureto reflux for 3 h
filtrationis collected by filtration
washthe residue is washed with ethanol
customdried in vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-563a2223e3b2475a85831acdb2feaa2f
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09246103B2

反应 SMILES

C[O:2][C:3](=[O:41])[C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[CH:6][C:5]=1[C:11]1[CH:23]=[CH:22][C:21]2[C:20]3[C:15](=[CH:16][C:17]([Br:24])=[CH:18][CH:19]=3)[C:14]([CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[C:13]=2[CH:12]=1.[OH-].[K+].C(O)C>C(O)C>[Br:10][C:8]1[CH:7]=[CH:6][C:5]([C:11]2[CH:23]=[CH:22][C:21]3[C:20]4[C:15](=[CH:16][C:17]([Br:24])=[CH:18][CH:19]=4)[C:14]([CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[C:13]=3[CH:12]=2)=[C:4]([CH:9]=1)[C:3]([OH:41])=[O:2]