反应详情

10g (0.06 mol) of 2,3-dichloromaleic anhydride was dissolved in 100 ml of water. Then to the resulting solution 5.55g (0.05 mol) of 4-fluoroaniline was added dropwise over a period of 5 min. at room temperatures under agitation. The mixture was then allowed to react for 15 hours at 60° C. Upon cooling the reaction mixture, precipitated crystal was separated by filtration to obtain 11.9g of N-(4-fluorophenyl)-2,3-dichloromaleimide melting at 239°-242° C (not corrected) at a yield of 91.5%. An analysis by gas chromatography showed the product had a purity of 97.9%.

1. customto react for 15 hours at 60° C
2. temperatureUpon cooling the reaction mixture
3. customprecipitated crystal
4. customwas separated by filtration