4-Fluoroaniline → HCID 21450978, compound

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Reaction Steps

8.35g (0.05 mol) of 2,3-dichloromaleic anhydride was dissolved in 50 ml of benzene. To the resulting solution 20 ml of benzene solution containing 5.55g (0.05 mol) of 4-fluoroaniline was added dropwise over a period of 20 min. at temperatures of 5°-10° C under agitation. After completing the addtion, the mixture was agitated at 5°-10° C for 30 min. to form crystals, which were separated by filtration and washed with benzene to obtain 13.15g of N-(4-fluorophenyl)-2,3-dichloromaleamic acid in the form of white crystal melting at 222°-225° C (yield, 95%). The results of elementary analysis were as follows:

Provenance & Evidence