Dimethylcarbamoyl Chloride → HCID 21450980, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2.8 g of 5-(3,4-dichlorophenyl)-7-ethyl-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepine in 50 ml of pyridine is added 1.3 g of dimethylcarbamoyl chloride, and stirred for 24 hours at 60° C. Then pyridine is evaporated under reduced pressure. To the residue is added acetone to crystallize. The crude crystals obtained are recrystallized from ethanol to give 1.3 g of 5-(3,4-dichlorophenyl)-7-ethyl-1-dimethylcarbamoyl-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepine hydrochloride as pale yellow crystals, melting at 219°-221° C with decomposition.

Provenance & Evidence