HCID 21451008, compound → HCID 86734519, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5.8 g of 5-o-chlorophenyl-7-ethyl-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepine in 50 ml of pyridine is added 4.2 g of 2-piperidinoethylcarbamoyl chloride, and the mixture is stirred for 24 hours at 60° C. Then pyridine is evaporated under reduced pressure, and to the residue is added acetone to crystallize. The crude crystals obtained are recrystallized from ethanol to give 5-o-chlorophenyl-7-ethyl-1-(2-piperidinoethylcarbamoyl)-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepine dihydrochloride 1/2hydrate as yellow crystals, melting at 215°-216° C with decomposition.

Provenance & Evidence