Dimethylcarbamoyl Chloride → HCID 21450995, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 5.1 g of 7-ethyl-5-(2-pyridyl)-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepine in 50 ml of pyridine is added 2.4 g of dimethylcarbamoyl chloride, and stirred for 24 hours at 60° C. Then pyridine is evaporated under reduced pressure. To the residue is added acetone to crystallize. The crude crystals obtained are recrystallized from ethanol to give 7-ethyl-1-dimethylcarbamoyl-5-(2-pyridyl)-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepine dihydrochloride, melting at 183°-192° C with decomposition.

Provenance & Evidence