反应详情

A solution of 2-hydroxyimino-2-phenylacetonitrile (7.3 g), dimethylaniline (6.0 g.) and tert-butyl alcohol (3.7 g.) in benzene (50 ml.) was dropwise added to a solution of phosgene (5.0 g.) in benzene (50 ml.) over 30 minutes under ice-cooling. To the mixture was dropwise added a solution of pyridine (4.0 ml.) in benzene (20 ml.) and the mixture was stirred for 1 hour at the same temperature and allowed to stand overnight. Water and benzene were added to the reaction mixture and an insoluble material was filtered off. The organic layer was in turn washed with 1N hydrochloric acid, water, a sodium bicarbonate aqueous solution and water, and dried over magnesium sulfate. The solvent was distilled off and to the residue were added n-hexane and a small amount of methanol. An insoluble material was filtered off and the filtrate was concentrated. Methanol was added to the residue and the mixture was allowed to stand. The precipitates were collected by filtration to give 2-tert-butoxycarbonyloxyimino-2-phenylacetonitrile (3.5 g.). Mp 83° to 85° C. Water was added to the mother liquor and the mixture was allowed to stand. The precipitates were collected by filtration to give the object compound (1.5 g.). Total yield (5.0 g.).

1. temperaturecooling
2. waitto stand overnight
3. filtrationan insoluble material was filtered off
4. washwashed with 1N hydrochloric acid, water
5. dry with materiala sodium bicarbonate aqueous solution and water, and dried over magnesium sulfate
6. distillationThe solvent was distilled off and to the residue
7. additionwere added n-hexane
8. filtrationAn insoluble material was filtered off
9. concentrationthe filtrate was concentrated
10. additionMethanol was added to the residue
11. filtrationThe precipitates were collected by filtration