Sulfuric Acid → 2-Hydroxyimino-2-(1-naphthyl)acetonitrile

Participants

Reaction Steps

2-(1-naphthyl)acetonitrile (16.7 g.) was added to a solution of sodium hydroxide (4.2 g.) in methanol (80 ml.). To the mixture was introduced under ice-cooling gaseous methyl nitrite which was prepared by adding a solution of conc sulfuric acid (5 ml.) in water (10 ml.) to a solution of sodium nitrite (8.3 g.) in a mixture of methanol (5.5 ml.) and water (5 ml.). The mixture was stirred for 4 hours at the same temperature and the reaction mixture was treated by conventional method to give 2-hydroxyimino-2-(1-naphthyl)acetonitrile (7.1 g.), oil.

Provenance & Evidence