HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → N-2-ethyl-cyclohexylamino-3,4,5-trimethoxy-benzoate-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3,4,5-Trimethoxybenzoic Acid | HCID 8357 | — |
| Reactant | Cyclohexylamino-ethanol-hydrochloride | HCID 20534156 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | N-2-ethyl-cyclohexylamino-3,4,5-trimethoxy-benzoate-hydrochloride | HCID 88821243 | — |
Reaction Steps
2.0 g of 3,4,5-trimethoxy-benzoic acid, 1.8 g. of cyclohexylamino-ethanol-hydrochloride and 4.0 g. of p-toluene-sulphonic acid are refluxed in 40 ml. of benzene for 12 hours. After cooling the reaction mixture is extracted with a 15% sodium carbonate solution and 10% hydrochloric acid. White crystals precipitate from the hydrochloric acid solution. Thus N-2-ethyl-cyclohexylamino-3,4,5-trimethoxy-benzoate-hydrochloride is obtained. Mp.: 207°-208° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04010193 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-149f655c77f34aeca4d75bdad0a91374 |
| Source note | uspto-grants-1977_03 |