HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-2-ethyl-cyclohexylamino-3,4,5-trimethoxy-benzoate-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Benzoyl chloride, 3,4,5-trimethoxy- | HCID 78282 | — |
| Reactant | Cyclohexylamino ethanol | HCID 20285879 | — |
| Product | N-2-ethyl-cyclohexylamino-3,4,5-trimethoxy-benzoate-hydrochloride | HCID 88821243 | — |
Reaction Steps
2.86 g. of cyclohexylamino-ethanol are dissolved in 50 ml. of anhydrous ethyl acetate, whereupon gaseous hydrochloric acid is introduced until a pH value of 1 is reached. 4.61 g. of 3,4,5-trimethoxy-benzoyl chloride are added and the reaction mixture is refluxed under stirring for 8 hours. After cooling the precipitated crystalline mass is filtered by suction. 6.9 g. of N-2-ethyl-cyclohexylamino-3,4,5-trimethoxy-benzoate-hydrochloride are obtained. Mp.: 206°-208° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04010193 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-8d78f5cfb00a4821ac64d30e812cfb66 |
| Source note | uspto-grants-1977_03 |