Cyclobutanone → HCID 20316891, compound

HRID 596249Notes

Reaction equation

HRID 596249 reaction equation
[ClH:1].[NH2:2][CH:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:15][CH3:16])[C:9]=2[O:13][CH3:14])[C:4]1=[O:17].[C:18]1(=O)[CH2:21][CH2:20][CH2:19]1>>[ClH:1].[CH:18]1([NH:2][CH:3]2[CH2:12][CH2:11][C:10]3[C:5](=[CH:6][CH:7]=[C:8]([O:15][CH3:16])[C:9]=3[O:13][CH3:14])[C:4]2=[O:17])[CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 14496CyclobutanoneHCID 12353614HCID 12353614, compound

Product 1

HCID 20316891HCID 20316891, compound

Procedure

In a manner similar to that of Reference Example 3, 10.5 parts of 2-amino-5,6-dimethoxy-3,4-dihydro-1(2H)-naphthalenone hydrochloride is reacted with 10 volume parts of cyclobutanone. The procedure yields 8.2 parts of 2-cyclobutylamino-5,6-dimethoxy-3,4-dihydro-1(2H)-naphthalenone hydrochloride. Melting point: 146°-164° C (decomposition).

Sources & evidence

ORD record
ord-144daf8aa367478f870f1c9724ce5ef0
Source dataset
uspto-grants-1977_03
Patent number
US04010202

Reaction notes

Loading…