HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → Methyl 3-amino-4-phenoxy-5-sulfamoylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Methyl 3-nitro-4-phenoxy-5-sulfamoylbenzoate | HCID 53854447 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 3-amino-4-phenoxy-5-sulfamoylbenzoate | HCID 13020993 | — |
Reaction Steps
35 g (~0.1 mol) of 3-nitro-4-phenoxy-5-sulphamylbenzoic acid methyl ester are suspended in 150 ml of methanol and are hydrogenated with Raney nickel (5-10%) in an autoclave at 40° -50° and 100 atmospheres gauge. The precipitated amino compound is dissolved by the addition of acetone on a steambath and the Raney nickel is removed by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04010273 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-4b4e7f7afe7242e5aa1e774e7e31fda2 |
| Source note | uspto-grants-1977_03 |