HuagongsheHuagongshe Chemistry Print Report · For research reference only
Succinic anhydride → Methyl 3-(aminosulfonyl)-4-chloro-5-(2,5-dioxo-1-pyrrolidinyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Succinic anhydride | HCID 7922 | — |
| Reactant | HCID 54437081 | HCID 54437081 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 3-(aminosulfonyl)-4-chloro-5-(2,5-dioxo-1-pyrrolidinyl)benzoate | HCID 12498325 | — |
Reaction Steps
25.4 g of 4-chloro-3-amino-5-sulphamyl-benzoic acid methyl ester, m.p. 195°-196° C, are thoroughly mixed with 25 g of succinic acid anhydride and melted for 6 hours at 180° C. The melt is allowed to cool slowly and CH3OH is added carefully. The product crystallizes. A small amount of water added completes the crystallisation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04010273 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-53f156ff78f240e78b350c5a5c673249 |
| Source note | uspto-grants-1977_03 |