HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 3-aminosulfonyl-4-phenoxy-5-(1-pyrrolidinyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Piretanide | HCID 4849 | — |
| Product | Methyl 3-aminosulfonyl-4-phenoxy-5-(1-pyrrolidinyl)benzoate | HCID 11545297 | — |
Reaction Steps
36.2 g of 4-phenoxy-3-(1-pyrrolidinyl)-5-sulphamoylbenzoic acid are dissolved in 200 ml of methanol and 7 ml of concentrated H2SO4 and heated for 4 to 6 hours under reflux. Upon cooling, the ester crystallises. Recrystallisation from methanol; M.p. 191° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04010273 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-b30a1158e8e6424c8ac5c0dcb123a2f8 |
| Source note | uspto-grants-1977_03 |