Veratroyl chloride → HCID 21451937, compound

HRID 596321Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.[CH3:17][O:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][C:27]=1[O:28][CH3:29])[C:22](Cl)=[O:23]>>[CH3:17][O:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][C:27]=1[O:28][CH3:29])[C:22]([NH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)=[O:23]

Participants

Reactant 2

HCID 77070Veratroyl chloride

HCID 14850211HCID 14850211, compound

Product 1

HCID 21451937HCID 21451937, compoundYield 60%

Procedure

4-[2-(3,4-Dimethoxy-benzamido)-ethyl]-4'-hydroxy-biphenyl was prepared analogous to Example I from 4-[2-amino-ethyl]-4'-hydroxy-biphenyl and 3,4-dimethoxybenzoyl chloride. Yield: 60% of theory; m.p. 170° C.

Sources & evidence

ORD record: ord-25242de2e38544cf91d744c4c03fd333
Source dataset: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04010279

Reaction notes

Loading…