Methyl 2-bromo-2-methylpropionate → HCID 21451954, compound

HRID 596323Notes

Reaction equation

HRID 596323 reaction equation
[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:4]=1[C:5]([NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)=[O:6].Br[C:29]([CH3:35])([CH3:34])[C:30]([O:32][CH3:33])=[O:31]>>[CH3:34][C:29]([O:22][C:19]1[CH:20]=[CH:21][C:16]([C:13]2[CH:12]=[CH:11][C:10]([CH2:9][CH2:8][NH:7][C:5](=[O:6])[C:4]3[CH:23]=[C:24]([Cl:27])[CH:25]=[CH:26][C:3]=3[O:2][CH3:1])=[CH:15][CH:14]=2)=[CH:17][CH:18]=1)([CH3:35])[C:30]([O:32][CH3:33])=[O:31]

Participants

3

Reactant 2

HCID 90097Methyl 2-bromo-2-methylpropionateHCID 21418526HCID 21418526, compound

Product 1

HCID 21451954HCID 21451954, compoundYield 19%

Procedure

Methyl 2-Methyl-2-{4-[2-(2-methoxy-5-chloro-benzamido)-ethyl]biphenyl-4'-oxy}-propionate was prepared from 4-[2-(2-methoxy-5-chloro-benzamido)-ethyl]-4'-hydroxy-biphenyl and methyl 2-bromo-2-methyl-propionate analogous to Example 1. Yield: 19% of theory; m.p. <20° C.

Sources & evidence

ORD record
ord-b670fbf31c6b4a90b0a8cfa7294db7e3
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

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