Ethyl 2-bromopropionate → HCID 21451936, compound

HRID 596324Notes

Reaction equation

HRID 596324 reaction equation
[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:4]=1[C:5]([NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)=[O:6].Br[CH:29]([CH3:35])[C:30]([O:32][CH2:33][CH3:34])=[O:31]>>[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:4]=1[C:5]([NH:7][CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH:29]([CH3:35])[C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:18][CH:17]=2)=[CH:14][CH:15]=1)=[O:6]

Participants

3

Reactant 2

HCID 79040Ethyl 2-bromopropionateHCID 21418526HCID 21418526, compound

Product 1

HCID 21451936HCID 21451936, compoundYield 26%

Procedure

Ethyl 2-{4-[2-(2-methoxy-5-chloro-benzamido)-ethyl]-biphenyl-4'-oxy}-propionate was prepared from 4-[2-(2-methoxy-5-chlorobenzamido)-ethyl]-4'-hydroxy-biphenyl and ethyl 2-bromo-propionate analogous to Example 1. Yield: 26% of theory; m.p. <20° C.

Sources & evidence

ORD record
ord-55d6f379dab2430488724e981e1aebc7
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

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