Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 21451934, compound

HRID 596326Notes

Reaction equation

HRID 596326 reaction equation
[C:1]([NH:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=2)=[CH:14][CH:13]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:26]([CH3:33])([CH3:32])[C:27]([O:29][CH2:30][CH3:31])=[O:28]>>[CH3:32][C:26]([O:24][C:21]1[CH:20]=[CH:19][C:18]([C:15]2[CH:16]=[CH:17][C:12]([CH2:11][CH2:10][NH:9][C:1](=[O:8])[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:13][CH:14]=2)=[CH:23][CH:22]=1)([CH3:33])[C:27]([O:29][CH2:30][CH3:31])=[O:28]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 21451933HCID 21451933, compound

Product 1

HCID 21451934HCID 21451934, compoundYield 16%

Procedure

Ethyl 2-Methyl-2-{4-[2-benzamido-ethyl]-biphenyl-4'-oxy}-propionate was prepared from 4-(2-benzamido-ethyl)-4'-hydroxybiphenyl and ethyl 2-bromo-2-methyl-propionate analogous to Example 1. Yield: 16% of theory; m.p. 100° C.

Sources & evidence

ORD record
ord-c4476ae9b2ec4955a478e5215c9c18c0
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

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