Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 21451956, compound

HRID 596327Notes

Reaction equation

HRID 596327 reaction equation
[CH3:1][C:2]1[CH:25]=[CH:24][C:5]([C:6]([NH:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=3)=[CH:13][CH:12]=2)=[O:7])=[CH:4][CH:3]=1.Br[C:27]([CH3:34])([CH3:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29]>>[CH3:33][C:27]([O:23][C:20]1[CH:21]=[CH:22][C:17]([C:14]2[CH:15]=[CH:16][C:11]([CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:5]3[CH:4]=[CH:3][C:2]([CH3:1])=[CH:25][CH:24]=3)=[CH:12][CH:13]=2)=[CH:18][CH:19]=1)([CH3:34])[C:28]([O:30][CH2:31][CH3:32])=[O:29]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 21451969HCID 21451969, compound

Product 1

HCID 21451956HCID 21451956, compoundYield 17%

Procedure

Ethyl 2-Methyl-2-{4[2-(4-methyl-benzamido)-ethyl]-biphenyl-4'-oxy}-propionate was prepared from 4-[2-(4-methyl-benzamido)-ethyl]-4'-hydroxy-biphenyl and ethyl 2-bromo-2-methyl-propionate analogous to Example 1. Yield 17% of theory; m.p. 214° C.

Sources & evidence

ORD record
ord-3dc43fff4ec04c1fb8d03e391d750e65
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

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