Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 21451922, compound

HRID 596328Notes

Reaction equation

HRID 596328 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][C:5]([C:6]([NH:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=3)=[CH:13][CH:12]=2)=[O:7])=[CH:4][CH:3]=1.Br[C:27]([CH3:34])([CH3:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29]>>[CH3:33][C:27]([O:23][C:20]1[CH:21]=[CH:22][C:17]([C:14]2[CH:15]=[CH:16][C:11]([CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:5]3[CH:24]=[CH:25][C:2]([F:1])=[CH:3][CH:4]=3)=[CH:12][CH:13]=2)=[CH:18][CH:19]=1)([CH3:34])[C:28]([O:30][CH2:31][CH3:32])=[O:29]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 21451959HCID 21451959, compound

Product 1

HCID 21451922HCID 21451922, compoundYield 20%

Procedure

Ethyl 2-Methyl-2-{4-[2-(4-fluoro-benzamido)-ethyl]-biphenyl-4'-oxy}-propionate was prepared from 4-[2-(4-fluoro-benzamido)ethyl]-4'-hydroxy-biphenyl and ethyl 2-bromo-2-methyl-propionate analogous to Example 1. Yield: 20% of theory; m.p. 135° C.

Sources & evidence

ORD record
ord-c42fd91df8d74a71a358e1222a921ae9
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

Loading…