Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 21451966, compound

HRID 596329Notes

Reaction equation

HRID 596329 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][CH:25]=1)[C:5]([NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)=[O:6].Br[C:27]([CH3:34])([CH3:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29]>>[CH3:33][C:27]([O:22][C:19]1[CH:20]=[CH:21][C:16]([C:13]2[CH:14]=[CH:15][C:10]([CH2:9][CH2:8][NH:7][C:5](=[O:6])[C:4]3[CH:23]=[CH:24][CH:25]=[C:2]([CH3:1])[CH:3]=3)=[CH:11][CH:12]=2)=[CH:17][CH:18]=1)([CH3:34])[C:28]([O:30][CH2:31][CH3:32])=[O:29]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 21451945HCID 21451945, compound

Product 1

HCID 21451966HCID 21451966, compoundYield 19%

Procedure

Ethyl 2-Methyl-2-{4-[2-(3-methyl-benzamido)-ethyl]-biphenyl-4'-oxy}-propionate was prepared from 4-[2-(3-methyl-benzamido)-ethyl]-4'-hydroxy-biphenyl and ethyl 2-bromo-2-methyl-propionate analogous to Example 1. Yield 19% of theory; m.p. <20° C.

Sources & evidence

ORD record
ord-6bcee4f0d1b44110a8e5789399cdfcf9
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

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