Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 21451924, compound

HRID 596330Notes

Reaction equation

HRID 596330 reaction equation
[CH3:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[C:4]([NH:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)=[O:5].Br[C:27]([CH3:34])([CH3:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29]>>[CH3:33][C:27]([O:21][C:18]1[CH:19]=[CH:20][C:15]([C:12]2[CH:13]=[CH:14][C:9]([CH2:8][CH2:7][NH:6][C:4](=[O:5])[C:3]3[CH:22]=[CH:23][CH:24]=[CH:25][C:2]=3[CH3:1])=[CH:10][CH:11]=2)=[CH:16][CH:17]=1)([CH3:34])[C:28]([O:30][CH2:31][CH3:32])=[O:29]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 21451943HCID 21451943, compound

Product 1

HCID 21451924HCID 21451924, compoundYield 20%

Procedure

Ethyl 2-Methyl-2-{4-[2-(2-methyl-benzamido)-ethyl]-biphenyl-4'-oxy}-propionate was prepared from 4-[2-(2-methyl-benzamido)-ethyl]-4'-hydroxy-biphenyl and ethyl 2-bromo-2-methyl-propionate analogous to Example 1. Yield: 20% of theory; m.p. <20° C

Sources & evidence

ORD record
ord-1b08cb5dbe744a5daf9ebd0a335cae37
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

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