Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 21451946, compound

HRID 596331Notes

Reaction equation

HRID 596331 reaction equation
[C:1]1([CH2:7][C:8]([NH:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=3)=[CH:15][CH:14]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[C:27]([CH3:34])([CH3:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29]>>[CH3:33][C:27]([O:25][C:22]1[CH:23]=[CH:24][C:19]([C:16]2[CH:17]=[CH:18][C:13]([CH2:12][CH2:11][NH:10][C:8](=[O:9])[CH2:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:14][CH:15]=2)=[CH:20][CH:21]=1)([CH3:34])[C:28]([O:30][CH2:31][CH3:32])=[O:29]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 54005929HCID 54005929, compound

Product 1

HCID 21451946HCID 21451946, compoundYield 26%

Procedure

Ethyl 2-Methyl-2-{4-[2-(phenyl-acetamido)-ethyl]-biphenyl-4'-oxy}-propionate was prepared from 4-[2-(phenyl-acetamido)-ethyl]-4' -hydroxy-biphenyl and ethyl 2-bromo-2methyl-propionate analogous to Example 1. Yield: 26% of theory; m.p. <20° C.

Sources & evidence

ORD record
ord-32cbfcc6f80148c6ab3b4b8092e690f4
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

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