Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 21451968, compound

HRID 596332Notes

Reaction equation

HRID 596332 reaction equation
[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)(=[O:3])[CH3:2].Br[C:21]([CH3:28])([CH3:27])[C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[CH3:27][C:21]([O:19][C:16]1[CH:15]=[CH:14][C:13]([C:10]2[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][NH:4][C:1](=[O:3])[CH3:2])=[CH:8][CH:9]=2)=[CH:18][CH:17]=1)([CH3:28])[C:22]([O:24][CH2:25][CH3:26])=[O:23]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 21451960HCID 21451960, compound

Product 1

HCID 21451968HCID 21451968, compoundYield 20%

Procedure

Ethyl 2-Methyl-2-[4-(2-acetamido-ethyl)-biphenyl-4'-oxy]-propionate was prepared from 4-(2-acetamido-ethyl)-4'-hydroxybiphenyl and ethyl 2-bromo-2-methyl-propionate analogous to Example 1. Yield: 20% of theory; m.p. <20° C.

Sources & evidence

ORD record
ord-884a482161d84e1492d67e929bff0b35
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

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