Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 21451947, compound

HRID 596338Notes

Reaction equation

HRID 596338 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][C:26]=1[O:27][CH3:28])[C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)=[CH:13][CH:12]=1)=[O:7].Br[C:30]([CH3:37])([CH3:36])[C:31]([O:33][CH2:34][CH3:35])=[O:32]>>[CH3:36][C:30]([O:23][C:20]1[CH:21]=[CH:22][C:17]([C:14]2[CH:13]=[CH:12][C:11]([CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:5]3[CH:24]=[CH:25][C:26]([O:27][CH3:28])=[C:3]([O:2][CH3:1])[CH:4]=3)=[CH:16][CH:15]=2)=[CH:18][CH:19]=1)([CH3:37])[C:31]([O:33][CH2:34][CH3:35])=[O:32]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 21451937HCID 21451937, compound

Product 1

HCID 21451947HCID 21451947, compoundYield 22%

Procedure

Ethyl 2-methyl-2-{4-[2-(3,4-dimethoxy-benzamido)-ethyl]-biphenyl-4'-oxy}-propionate was prepared from 4-[2-(3,4-dimethoxy-benzamido)-ethyl]-4'-hydroxy-biphenyl and ethyl 2-bromo-2-methyl-propionate analogous to Example 31. Yield: 22% of theory; m.p. 118° C.

Sources & evidence

ORD record
ord-f5955acbd54445d7acfbae36634baf39
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

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